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4SC AG
Ansprechpartner: 4SC AG
Tel.: +49 89 700763-0
E-Mail: ir-pr@4sc.com
pta20200928006
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4SC AG: 4SC AG announces publication of a new article on domatinostat


Planegg-Martinsried (pta006/28.09.2020/07:30) - 4SC AG (4SC, FSE Prime Standard: VSC) today announced the publication of a new article in Research Outreach, Health & Medicine authored by its Head of Research and Translational Medicine Svetlana Hamm Ph.D entitled "A New Weapon to Boost Cancer Immunotherapy". The article is freely accessible via https://researchoutreach.org or via the 4SC homepage.

Dr. Hamm commented: "Domatinostat alone, as well as in combination with checkpoint inhibition, is safe and well-tolerated in patients and is currently under evaluation in a broad set of clinical trials in patients with colorectal and gastric cancer, melanoma and merkel cell carcinoma. We published the first encouraging clinical and translational data on domatinostat at ESMO in 2019 and we look forward with great interest to see data from our broader clinical program with domatinostat in 2021 and 2022".

- Press release ends -

Further information
About 4SC
4SC AG is a clinical-stage biopharmaceutical company developing small-molecule drugs that can target key indications in cancer with high unmet medical needs. 4SC's pipeline is protected by a comprehensive portfolio of patents and currently comprises two drug candidates in clinical development: resminostat and domatinostat.
4SC aims to generate future growth and enhance its enterprise value by entering into partnerships with pharmaceutical and biotech companies and/or the eventual marketing and sales of approved drugs in select territories by 4SC itself.
4SC is headquartered in Planegg-Martinsried near Munich, Germany. The Company had 47 employees as of 30 June 2020 and is listed on the Prime Standard of the Frankfurt Stock Exchange (FSE Prime Standard: VSC; ISIN: DE000A14KL72).

About domatinostat
Domatinostat is an orally administered small molecule class I selective HDAC inhibitor. It strengthens the body's own anti-tumor immune response, influences the tumor and tumor microenvironment, making the tumor more visible to the immune system and facilitating the infiltration of immune cells into the tumor.
Domatinostat has been investigated in a Phase I study in 24 heavily pretreated patients with several types of advanced hematologic cancers and was well tolerated. Positive signs of anti-tumor efficacy were also observed; with one complete remission (28 months) and one partial responder (8 months).
In addition to its therapeutic potential in cancer monotherapy, 4SC is evaluating domatinostat's capacity as a partner in combination therapies, specifically in the immuno-oncology area. In this respect, 4SC initiated a Phase Ib/II study of domatinostat in combination with the anti-PD-1 checkpoint inhibitor pembrolizumab in patients with advanced-stage melanoma from which initial data was presented at ESMO 2019. A second Phase II study of domatinostat in combination with the anti-PD-L1 checkpoint inhibitor avelumab in patients with advanced-stage microsatellite-stable gastrointestinal cancer is currently being conducted by Prof. David Cunningham at The Royal Marsden NHS Foundation Trust in London, UK. And in collaboration with the Netherlands Cancer Institute in Amsterdam, the DONIMI Study, a multicenter, investigator-sponsored phase 1b study, testing the combination of domatinostat, nivolumab, and ipilimumab, in high risk stage III melanoma in the neoadjuvant setting.

Forward-looking information
Information set forth in this press release contains forward-looking statements, which involve risks and uncertainties. The forward-looking statements contained herein represent the judgement of 4SC as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond 4SC's control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. 4SC expressly disclaims any obligation or undertaking to release any updates or revisions to any such statements to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based.

Contact
4SC
ir-pr@4sc.com
+49 89 700763-0

(end)
emitter: 4SC AG
Fraunhoferstr. 22
82152 Planegg-Martinsried
Germany
contact person: 4SC AG
phone: +49 89 700763-0
e-mail: ir-pr@4sc.com
website: www.4sc.de
stock exchanges: regulated market in Frankfurt; free market in Dusseldorf, free market in Hamburg, free market in Munich, free market in Stuttgart; open market in Berlin, Tradegate
ISIN(s): DE0005753818 (share)
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